Expression and function of long non-coding RNA DLX6-AS1 in endometrial cancer
نویسندگان
چکیده
Background: LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers. Nevertheless, the impacts of endometrial cancer (EC) development remained obscure. The study explored influence EC progression via microRNA (miR)-374a-3p/zinc-finger protein (ZFX) axis.Methods: cell lines were collected and DLX6-AS1, miR-374a-3p, ZFX levels in detected. cells transfected with constructs examine biological functions cells. xenograft model was established for detecting tumor growth. Rescue experiments conducted verify interaction cells.Results: elevated, while miR-374a-3p exhibited a reduced level Silencing elevated expressions repressed activities Reduced development. MiR-374a-3p silencing reversed silencing, overexpression abrogated elevation Mechanically, found bind targeted ZFX.Conclusion: depletion restricts malignant phenotype might provide novel therapeutic biomarkers treatment.
منابع مشابه
Long Non-coding RNA ZEB1-AS1 Promotes Tumorigenesis and Metastasis in Colorectal Cancer
Emerging evidence implicates that a large fraction of human genome was transcribed but the transcripts known as long non coding RNA are not translated into proteins. They are contributing in different cellular processes, including cellular proliferation and apoptosis. LncRNAs were found to play critical roles in many diseases and act as key regulators in malignancies. In this study, we investig...
متن کاملDysregulated Expression of Long Non-Coding RNA MINCR and EZH2 in Colorectal Cancer
Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known. Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorect...
متن کاملEvaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer
Background: Breast cancer is one of the major causes of illness and mortality among women. Long non-coding RNAs (LncRNAs) have important role in tumor development and progression. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that deregulates in several cancers, however, its value in the diagnosis of breast cancer is unclear. This study was conducted to investigate...
متن کاملClinical and in vitro Study of Novel Long Non-Coding RNA lncUSMycN in Breast Cancer Cancer
Background: Despite recent advances in diagnosis and treatment, breast cancer remains a leading cause of death in women worldwide. Long non-coding RNAs are a new class of RNA molecules that have been shown to participate in tumorigenesis. The aim of this study was to investigate the expression of lncUSMycN in tumor samples and to evaluate its potential role in the breast cancer cell line. Metho...
متن کاملExpression and clinical significance of long non-coding RNA HNF1A-AS1 in human gastric cancer
BACKGROUND Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play essential roles in the occurrence and development of human cancers, including gastric cancer (GC). However, the functional and clinical significance of lncRNAs are still poorly understood. METHODS In this study, the expression of LncRNA HNF1A antisense RNA 1 (HNF1A-AS1) was first examined by lncRNAs micro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biocell
سال: 2023
ISSN: ['0327-9545', '1667-5746']
DOI: https://doi.org/10.32604/biocell.2023.026037